Traumatic Brain Injury-Induced Acute Lung Injury: Evidence for Activation and Inhibition of a Neural-Respiratory-Inflammasome Axis.

@article{Kerr2018TraumaticBI,
  title={Traumatic Brain Injury-Induced Acute Lung Injury: Evidence for Activation and Inhibition of a Neural-Respiratory-Inflammasome Axis.},
  author={Nadine A Kerr and Juan Pablo de Rivero Vaccari and Sam Abbassi and Harmanpreet Kaur and Ronald Zambrano and Shu Qing Wu and W. Dalton Dietrich and Robert W Keane},
  journal={Journal of neurotrauma},
  year={2018},
  volume={35 17},
  pages={
          2067-2076
        }
}
Approximately 20-25% of traumatic brain injury (TBI) subjects develop acute lung injury (ALI), but the pathomechanisms of TBI-induced ALI remain poorly defined. Our previous work has shown that the inflammasome plays a critical role in TBI-induced secondary pathophysiology and that inflammasome proteins are released in extracellular vesicles (EV) after TBI. Here we investigated whether EV-mediated inflammasome signaling contributed to the etiology of TBI-induced ALI. C57/BL6 male mice were… CONTINUE READING
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