Traumatic Axonal Injury Induces Calcium Influx Modulated by Tetrodotoxin-Sensitive Sodium Channels

@article{Wolf2001TraumaticAI,
  title={Traumatic Axonal Injury Induces Calcium Influx Modulated by Tetrodotoxin-Sensitive Sodium Channels},
  author={J. A. Wolf and P. Stys and T. Lusardi and D. Meaney and D. Smith},
  journal={The Journal of Neuroscience},
  year={2001},
  volume={21},
  pages={1923 - 1930}
}
Diffuse axonal injury (DAI) is one of the most common and important pathologies resulting from the mechanical deformation of the brain during trauma. It has been hypothesized that calcium influx into axons plays a major role in the pathophysiology of DAI. However, there is little direct evidence to support this hypothesis, and mechanisms of potential calcium entry have not been explored. In the present study, we used an in vitro model of axonal stretch injury to evaluate the extent and… Expand
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