Trauma-induced alterations in cognition and Arc expression are reduced by previous exposure to 56Fe irradiation.

@article{Rosi2012TraumainducedAI,
  title={Trauma-induced alterations in cognition and Arc expression are reduced by previous exposure to 56Fe irradiation.},
  author={Susanna Rosi and Karim Belarbi and Ryan A. Ferguson and Kelly M. Fishman and Andre Obenaus and Jacob Raber and John Fike},
  journal={Hippocampus},
  year={2012},
  volume={22 3},
  pages={544-54}
}
Exposure to ionizing irradiation may affect brain functions directly, but may also change tissue sensitivity to a secondary insult such as trauma, stroke, or degenerative disease. To determine if a low dose of particulate irradiation sensitizes the brain to a subsequent injury, C56BL6 mice were exposed to brain only irradiation with 0.5 Gy of (56) Fe ions. Two months later, unilateral traumatic brain injury was induced using a controlled cortical impact system. Three weeks after trauma, animals… CONTINUE READING
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