Trauma-hemorrhagic shock-induced red blood cell damage leads to decreased microcirculatory blood flow.

@article{Machiedo2009TraumahemorrhagicSR,
  title={Trauma-hemorrhagic shock-induced red blood cell damage leads to decreased microcirculatory blood flow.},
  author={George W Machiedo and Sergey B Zaets and Tamara L. Berezina and Da-zhong Xu and Eleonora Feketova and Zolt{\'a}n Spolarics and Edwin A. Deitch},
  journal={Critical care medicine},
  year={2009},
  volume={37 3},
  pages={
          1000-10
        }
}
OBJECTIVE To test the hypothesis that trauma-hemorrhagic shock (T/HS)-induced changes in red blood cells (RBC) contribute to the reduction of blood flow in distant organs. DESIGN Laboratory study. SETTING Academic medical center laboratory. SUBJECTS Specific pathogen-free male Sprague-Dawley rats weighing between 250 and 350 g. INTERVENTIONS Rats were transfused with trauma-sham shock (T/SS), or T/HS whole blood, or RBC-depleted blood (blood with the RBC removed and consisting of white… CONTINUE READING

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