Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD

@article{Vanderheyden2014TraumaEA,
  title={Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD},
  author={William M Vanderheyden and Gina R. Poe and Israel Liberzon},
  journal={Experimental Brain Research},
  year={2014},
  volume={232},
  pages={1575-1584}
}
Post-traumatic stress disorder (PTSD) is characterized by intrusive memories of a traumatic event, avoidance behavior related to cues of the trauma, emotional numbing, and hyper-arousal. Sleep abnormalities and nightmares are core symptoms of this disorder. In this review, we propose a model which implicates abnormal activity in the locus coeruleus (LC), an important modifier of sleep–wake regulation, as the source of sleep abnormalities and memory abnormalities seen in PTSD. Abnormal LC… CONTINUE READING
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