Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen.

@article{Sabnis2009TrastuzumabRL,
  title={Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen.},
  author={Gauri J. Sabnis and Adam B. Schayowitz and Olga G. Goloubeva and Luciana Furtado Macedo and Angela M. H. Brodie},
  journal={Cancer research},
  year={2009},
  volume={69 4},
  pages={
          1416-28
        }
}
In this study, we investigated adaptive mechanisms associated with aromatase inhibitor (AI) resistance in breast cancer cells and show that sensitivity to AIs can be extended through dual inhibition of estrogen receptor (ER) and human epidermal receptor-2 (Her-2) signaling. We used human ER-positive breast cancer cells stably transfected with the aromatase gene (MCF-7Ca). These cells grow as tumors in nude mice and are inhibited by AIs. Despite continued treatment, tumors eventually become… CONTINUE READING

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Trastuzumab increases sensitivity of hormone depen dent and hormone refractory breast cancer cells to endocrine agents [abstract 991

GJ Sabnis, A Schayowitz, O Goloubeva, AMH. Brodie
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