Trastuzumab in gastric cancer.

  title={Trastuzumab in gastric cancer.},
  author={Alicia Okines and D. Hamish Cunningham},
  journal={European journal of cancer},
  volume={46 11},
Trastuzumab is a fully humanised monoclonal antibody directed at the human epidermal growth factor receptor-2 (HER-2) which has been a component of standard therapy for advanced and resected HER-2-positive breast cancers for almost a decade. HER-2 over-expression, defined as HER-2 protein over-expression using immunohistochemistry scored as 3+ and/or erbB-2 amplification detected by fluorescent in situ hybridisation, was detected in 22.1% of 3807 patients with advanced gastric and… CONTINUE READING
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