Trastuzumab administration during pregnancy: a systematic review and meta-analysis

  title={Trastuzumab administration during pregnancy: a systematic review and meta-analysis},
  author={Flora Zagouri and Theodoros N Sergentanis and Dimosthenis T Chrysikos and Christos Papadimitriou and Meletios Athanasios Dimopoulos and Rupert Bartsch},
  journal={Breast Cancer Research and Treatment},
Landmark studies have established trastuzumab in the treatment of HER2-positive breast cancer. The present systematic review and meta-analysis aims to synthesize all available data, so as to evaluate the safety of trastuzumab during pregnancy. This study was performed in accordance with the PRISMA guidelines. All studies that examined the safety of trastuzumab administered during pregnancy, regardless of sample size, were considered eligible. Overall, 17 studies (18 pregnancies; 19 newborns… CONTINUE READING