Trapping intracellular ANG II to the proximal tubule: powerful in vivo effects on sodium handling and blood pressure.

Abstract

THE RENIN-ANGIOTENSIN SYSTEM (RAS) acts as a dual endocrine and local tissue paracrine system (1, 6). There is increasing evidence that angiotensin (ANG) II may also function as an autocrine or intracrine peptide which exerts biological effects from within the cell without stimulating plasma membrane bound ANG II type 1 (AT1) receptors (2, 5). The autocrine… (More)
DOI: 10.1152/ajprenal.00115.2011

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