Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients.

@article{Lcureuil2007TrappingAA,
  title={Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients.},
  author={C{\'e}dric L{\'e}cureuil and B{\'e}hazine Combadi{\`e}re and Elodie Mazoyer and Olivia Bonduelle and Assia Samri and Brigitte Autran and Patrice Debr{\'e} and Christophe Combadi{\`e}re},
  journal={Blood},
  year={2007},
  volume={109 9},
  pages={3649-57}
}
CCR6, a homeostatic chemokine receptor, is shown here to characterize subsets of both central and effector memory T cells that secrete high levels of IL-2 and TNF-alpha in response to polyclonal and antigen-specific stimulation. CCR6(+) T lymphocytes disappeared dramatically from the peripheral blood of HIV-infected patients as HIV disease progressed. The capacity of CD4(+)CCR6(+) to secrete multiple cytokines remained intact among HIV-infected long-term nonprogressors but was partially lost… CONTINUE READING

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Cloning and characterization of a specific receptor for the 3656 LECUREUIL et al BLOOD, 1 MAY

CA Power, DJ Church, A Meyer
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