Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?
@article{Hurst1995TransverseLD, title={Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?}, author={J. Hurst and R. Houlston and A. Roberts and S. Gould and W. G. Tingey}, journal={Clinical Dysmorphology}, year={1995}, volume={4}, pages={359–363} }
&NA; Transverse limb defects are reported in a fetus and an infant born to mothers on treatment for hypertension. One pregnancy resulted in an intrauterine death at 20 weeks, and in addition to the limb defects, there was bilateral cleft lip and palate and renal hypoxic damage. It is proposed that the drugs caused maternal hypotension which led to reduced uteroplacental blood flow, fetal hypotension and hypoxia and that the anomalies seen in the two babies are a consequence of these events.
Topics from this paper
20 Citations
Bilateral cleft lip and palate, hypertelorism and hypoplastic toes.
- Medicine
- Clinical dysmorphology
- 2004
- 5
Chorion villus sampling and limb deficiency—cause or coincidence?
- Biology, Medicine
- Prenatal diagnosis
- 1997
- 56
Drugs in pregnancy. Antihypertensives.
- Medicine
- Best practice & research. Clinical obstetrics & gynaecology
- 2001
- 45
The effect of hypoxia in development.
- Biology, Medicine
- Birth defects research. Part C, Embryo today : reviews
- 2007
- 164
The safety of antihypertensives for treatment of pregnancy hypertension
- Medicine
- Expert opinion on drug safety
- 2004
- 7
Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy
- Biology, Medicine
- Molecular metabolism
- 2017
- 5
Unilateral Buccinator Flap for Lengthening of Short Palate
- Medicine
- The Journal of craniofacial surgery
- 2018
References
SHOWING 1-7 OF 7 REFERENCES
Analysis of limb reduction defects in babies exposed to chorionic villus sampling
- Medicine
- The Lancet
- 1994
- 147
Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation
- Biology, Medicine
- The Lancet
- 1991
- 344
Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity.
- Medicine
- Teratology
- 1992
- 58
Transverse limb deficiency, oro-mandibular limb hypogenesis sequences, and chorionic villus biopsy: human and animal experimental evidence for a uterine vascular pathogenesis.
- Biology, Medicine
- American journal of medical genetics
- 1993
- 18