Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?

  title={Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?},
  author={Jane A. Hurst and Richard S. Houlston and A Roberts and S Gould and W G Tingey},
  journal={Clinical Dysmorphology},
&NA; Transverse limb defects are reported in a fetus and an infant born to mothers on treatment for hypertension. One pregnancy resulted in an intrauterine death at 20 weeks, and in addition to the limb defects, there was bilateral cleft lip and palate and renal hypoxic damage. It is proposed that the drugs caused maternal hypotension which led to reduced uteroplacental blood flow, fetal hypotension and hypoxia and that the anomalies seen in the two babies are a consequence of these events. 

Non-Syndromic Cleft Palate and Transverse Limb Deficiency Segregating in a Family of Dogs

The morphology and genetic transmission of isolated cleft palate in a naturally occurring dog model constitutes a large animal model of non-syndromic isolated Cleft palate coincident with developmental limb deficiency.

Bilateral cleft lip and palate, hypertelorism and hypoplastic toes.

We report on a 23-month-old boy with bilateral cleft lip and palate, marked hypertelorism, frontal bossing and severe bilateral, asymmetric hypoplasia of toes. The mother used bisoprolol, naproxen

Chorion villus sampling and limb deficiency—cause or coincidence?

There is a diminishing risk for transverse limb deficiency with advancing gestation, and the risk of limb deficiency extends through the period of limb morphogenesis and slightly beyond.

Optimization of hypertension and embryo safe antihypertensives

The importance of preconception assessment and counseling to optimize pregnancy outcome is highlighted and the advantages and disadvantages of different antihypertensive drugs in pregnancy are summarized.

Drugs in pregnancy. Antihypertensives.

  • L. Magee
  • Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2001
Clinical trials indicate that transient severe hypertension, antenatal hospitalization, proteinuria at delivery and neonatal respiratory distress syndrome may be decreased by normalizing blood pressure, but intrauterine fetal growth restriction may be increased.

The effect of hypoxia in development.

  • W. WebsterD. Abela
  • Biology, Medicine
    Birth defects research. Part C, Embryo today : reviews
  • 2007
The strongest evidence of hypoxia causing birth defects in the human comes from studies of fetuses lacking hemoglobin (Hb) F, which are thought to be hypoxic from about the middle of the first trimester and show a range of birth defects, particularly transverse limb reduction defects.

The safety of antihypertensives for treatment of pregnancy hypertension

This review addresses the maternal and perinatal benefits and risks of antihypertensive therapy in pregnancy by covering the diagnosis of hypertension in pregnancy followed by both the general principles of management of pregnancy hypertension and the specifics of individual anti Hypertensive drugs and drug classes.

Treating Hypertension in Women of Child-Bearing Age and during Pregnancy

There is no consensus as to whether mild-to-moderate hypertension in pregnancy should be treated: the risks of transient severe hypertension, antenatal hospitalisation, proteinuria at delivery and neonatal respiratory distress syndrome may be decreased by therapy, but intrauterine fetal growth may also be impaired, particularly by atenolol.

Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy

Unilateral Buccinator Flap for Lengthening of Short Palate

Unilateral BMF is reliable, promising, and safe flap for lengthening of short palate and it can lengthen the palate up to 19 mm and speech improvement will achieve in 70% to 86% patients.



Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity.

The results suggest that vascular disruption due to a fetal hypoxic response lies behind phenytoin teratogenicity, as has been shown for vasodilators.

Limb reduction defects in over one million consecutive livebirths.

Limb reduction defects occurring among 1,213,913 consecutive livebirths in British Columbia during the period 1952-1984 inclusive were reviewed and found no evidence that one side is affected more frequently, and overall about one-half of the cases have additional defects.