Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.

  title={Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.},
  author={Xi Huang and Jiang Liu and Tatiana Ketova and Jonathan T. Fleming and Vandana K. Grover and Michael K. Cooper and Ying Litingtung and Chin Lee Chiang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 18},
Cerebellar neurons are generated from two germinal neuroepithelia: the ventricular zone (VZ) and rhombic lip. Signaling mechanisms that maintain the proliferative capacity of VZ resident progenitors remain elusive. We reveal that Sonic hedgehog (Shh) signaling is active in the cerebellar VZ and essential to radial glial cell proliferation and expansion of GABAergic interneurons. We demonstrate that the cerebellum is not the source of Shh that signals to the early VZ, and suggest a… CONTINUE READING
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