Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial

  title={Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial},
  author={Maria Rosa Costanzo and Piotr P Ponikowski and Shahrokh Javaheri and Ralph S Augostini and Lee R. Goldberg and Richard G. Holcomb and Andrew C Kao and Rami N. Khayat and Olaf Oldenburg and Christoph Stellbrink and William T. Abraham},
  journal={The Lancet},
BACKGROUND Central sleep apnoea is a serious breathing disorder associated with poor outcomes. The remedé system (Respicardia Inc, Minnetonka, MN, USA) is an implantable device which transvenously stimulates a nerve causing diaphragmatic contraction similar to normal breathing. We evaluated the safety and effectiveness of unilateral neurostimulation in patients with central sleep apnoea. METHODS We recruited patients from 31 hospital-based centres in Germany, Poland, and the USA in this… CONTINUE READING


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