Transvascular drug delivery in solid tumors.

  title={Transvascular drug delivery in solid tumors.},
  author={Fan Yuan},
  journal={Seminars in radiation oncology},
  volume={8 3},
  • Fan Yuan
  • Published 1998 in Seminars in radiation oncology
The microvessel wall is a barrier for the delivery of various therapeutic agents to tumor cells. Tumor microvessels are, in general, more permeable to macromolecules than normal vessels. The hyperpermeability is presumably due to the existence of large pore structures in the vessel wall, induced by various cytokines. The cutoff pore size is tumor dependent, as determined by transport studies of nanoparticles. The vascular permeability is heterogeneous in tumors and dependent on physicochemical… CONTINUE READING
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