Transvalencin Z, a New Antimicrobial Compound with Salicylic Acid Residue from Nocardia transvalensis IFM 10065

  title={Transvalencin Z, a New Antimicrobial Compound with Salicylic Acid Residue from Nocardia transvalensis IFM 10065},
  author={Akira Mukai and Toshio Fukai and Yuko Matsumoto and Jun Ishikawa and Yasutaka Hoshino and Katsukiyo Yazawa and Ken‐ichi Harada and Yuzuru Mikami},
  journal={The Journal of Antibiotics},
Transvalencin Z was isolated from a culture broth of Nocardia transvalensis IFM 10065, a clinical isolate from a Japanese patient with actinomycotic mycetoma. The transvalencin Z structure was determined using NMR and mass spectrometric analyses. The structure is similar to a partial structure of siderophores such as mycobactins and nocobactins, but the compound has no cytotoxic activity. Transvalencin Z shows a strong antimicrobial activity against Gram-positive bacteria, but shows no activity… 
Total synthesis and biological evaluation of transvalencin Z.
Surprisingly, none of the transvalencin Z diastereomers exhibited any inhibitory activity against a panel of microbial pathogens, including several species of mycobacteria.
Novel siderophore, JBIR-16, isolated from Nocardia tenerifensis NBRC 101015
In the course of the screening program for biologically active compounds of microbial origin, a novel heterobactin12 analog, JBIR-16 (1), containing hydroxamate and catecholate, was isolated from the culture broth of Nocardia tenerifensis NBRC 101015, revealing the characteristic absorptions of amide carbonyl and amide N–H groups.
Production, Partial Purification and Antitumor Properties of Bioactive Compounds from Locally Isolated Actinomycetes (KH14)
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The study has demonstrated that N. brasiliensis PTCC 1422 has a high potential for the treatment of UTIs and indicates that the substances present in the N. brailensis PT CC 1422 could be used to inhibit the growth of human pathogen.
713A, a new metabolite isolated from a fungal strain 713.
A new compound named 713A was isolated from the fermentation broth of a fungal strain 713 and exhibited inhibitory activity to the binding of IL-6 andIL-6 receptor with an IC50 value of 8.6 microM.
Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6.
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The infection caused by drug-resistant pathogens, such as cancer and cardiovascular diseases, are major causes of mortality in the world. Diverse bioactive molecules isolated from microbial or plant


Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. I. Taxonomy, fermentation, isolation and biological activities.
A new thiazolidine-type antibiotic with zinc in its structure, designated transvalencin A, was isolated from Nocardia sp. IFM 10065, a clinical isolate from a patient with actinomycotic mycetoma. The
Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation.
A novel antifungal antibiotic, transvalencin A, is produced by Nocardia transvalensis IFM 10065 isolated from a patient with actinomycotic mycetoma in Japan and elucidated using NMR, mass spectrometric investigations, and X-ray crystallographic analysis.
Brasilibactin A, a cytotoxic compound from actinomycete Nocardia brasiliensis.
A new cytotoxic compound, brasilibactin A (1), has been isolated from the actinomycete Nocardia brasiliensis IFM 0995, and the structure was elucidated on the basis of spectroscopic data and chemical
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Three novel pentapeptides that were acylated with salicylic acid at the N-terminus, isolated from the culture broth of a pathogenic Actinomadura madurae IFM 0745 strain had an antibacterial activity against Micrococcus luteus, indicating that the presence of the aziridine ring is essential for such activity.
The complete genomic sequence of Nocardia farcinica IFM 10152.
The genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and the molecular basis of its versatility are determined, suggesting that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.
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The nocardiae are facultative intracellular pathogens that can persist within the host, probably in a cryptic form (L-form), for life and are an important part of the normal soil microflora worldwide.
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Discovery of methyl-2-(2'-hydroxyphenyl)-2-oxazoline-4-carboxylate as a secondary metabolite from Actinomadura sp.
recommended by Shirling and Gottlieb1}. The strain exhibited the following cultural characteristics during incubation for 3 weeks at 27°C in various media. It formed well-branched substrate mycelium
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