Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell

Abstract

Transthyretin (TTR) is a functional protein in the pancreatic β-cell. It promotes insulin release and protects against β-cell death. We now demonstrate by ligand blotting, adsorption to specific magnetic beads, and surface plasmon resonance that TTR binds to glucose-regulated proteins (Grps)78, 94, and 170, which are members of the endoplasmic reticulum… (More)
DOI: 10.1007/s00018-011-0899-8

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