Transsynaptic transfer of retrogradely transported tetanus protein-peroxidase conjugates.

@article{Fishman1989TranssynapticTO,
  title={Transsynaptic transfer of retrogradely transported tetanus protein-peroxidase conjugates.},
  author={Paul S. Fishman and Joseph Joan B. Kessler Janet I. Levine Donna D. Melby Ell Savitt},
  journal={Experimental neurology},
  year={1989},
  volume={106 2},
  pages={197-203}
}
Tetanus toxin and its atoxic binding fragment, C-fragment (CF), are the only known proteins which undergo extensive transfer from motoneurons to presynaptic terminals in the spinal cord. Intramuscular injection of CF conjugated to horseradish peroxidase (HRP) was used to elucidate the ultrastructural basis for this unique property. Motoneurons labeled by retrograde axonal transport contained enzymatic reaction product within cytoplasmic vesicles and were surrounded by presynaptic terminals with… CONTINUE READING