Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine beta-synthase.

@article{Maclean2000TranssulfurationIS,
  title={Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine beta-synthase.},
  author={Kenneth N. Maclean and Miroslav Janos{\'i}k and Jana Oliveriusov{\'a} and Vladim{\'i}r Kery and Jan P Kraus},
  journal={Journal of inorganic biochemistry},
  year={2000},
  volume={81 3},
  pages={161-71}
}
Cystathionine beta-synthase [CBS; L-serine hydro-lyase (adding homocysteine), EC 4.2.1.22] catalyzes the first committed step of transsulfuration in both yeast and humans. It has been established previously that human CBS is a hemeprotein but although the heme group appears to be essential for CBS activity, the exact function of the heme group is unknown. CBS activity is absent in heme deficient strains of Saccharomyces cerevisiae grown without heme supplementation. CBS activity can be restored… CONTINUE READING
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