Transrepression of estrogen receptor beta signaling by nuclear factor-kappab in ovarian granulosa cells.

@article{Chu2004TransrepressionOE,
  title={Transrepression of estrogen receptor beta signaling by nuclear factor-kappab in ovarian granulosa cells.},
  author={Simon Chu and Yoshihiro Nishi and Toshihiko Yanase and Hajime Nawata and Peter J. Fuller},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 8},
  pages={1919-28}
}
Estrogen receptor (ER) beta is the predominant ER in granulosa cells of the ovary. ERbeta is expressed at high levels in granulosa cell tumors (GCT) and in the human GCT-derived cell lines, COV434 and KGN. To gain insight into ERbeta function in granulosa cells and in GCT, we have used the COV434 and KGN cell lines. Although the cells bind estradiol (E2), transcriptional activation of a transfected estrogen-responsive reporter vector construct (ERE2-luc) by E2 was not observed. Transactivation… CONTINUE READING