Transposon vectors for gene-trap insertional mutagenesis in vertebrates.

@article{Clark2004TransposonVF,
  title={Transposon vectors for gene-trap insertional mutagenesis in vertebrates.},
  author={Karl J. Clark and Aron M Geurts and Jason B. Bell and Perry B. Hackett},
  journal={Genesis},
  year={2004},
  volume={39 4},
  pages={225-33}
}
The function of most vertebrate genes remains unknown or uncertain. Insertional mutagenesis offers one approach to identify and understand the function of these genes. Transposons have been used successfully in lower organisms and plants for insertional mutagenesis, but until activation of the Sleeping Beauty (SB) transposon system, there was no indication of active DNA-based transposons in vertebrates. Investigator-driven insertional mutagenesis in vertebrates has relied on retroviral… CONTINUE READING
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