Transposon mutagenesis of type III group B Streptococcus: correlation of capsule expression with virulence.

@article{Rubens1987TransposonMO,
  title={Transposon mutagenesis of type III group B Streptococcus: correlation of capsule expression with virulence.},
  author={Craig E. Rubens and Michael R. Wessels and L M Heggen and Dennis L Kasper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 20},
  pages={7208-12}
}
The capsular polysaccharide of type III group B Streptococcus (GBS) is thought to be a major factor in the virulence of this organism. Transposon mutagenesis was used to obtain isogenic strains of a GBS serotype III clinical isolate (COH 31r/s) with site-specific mutations in the gene(s) responsible for capsule production. The self-conjugative transposon Tn916 was transferred to strain COH 31r/s during incubation with Streptococcus faecalis strain CG110 on membrane filters. Eleven… CONTINUE READING
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