Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression

@article{Takeda2015TransposonMI,
  title={Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression},
  author={Haruna Takeda and Zhubo Wei and Hideto Koso and Alistair G. Rust and Christopher Chin Kuan Yew and Michael B. Mann and Jerrold M Ward and David J. Adams and Neal G. Copeland and Nancy A. Jenkins},
  journal={Nature Genetics},
  year={2015},
  volume={47},
  pages={142-150}
}
To provide a more comprehensive understanding of the genes and evolutionary forces driving colorectal cancer (CRC) progression, we performed Sleeping Beauty (SB) transposon mutagenesis screens in mice carrying sensitizing mutations in genes that act at different stages of tumor progression. This approach allowed us to identify a set of genes that appear to be highly relevant for CRC and to provide a better understanding of the evolutionary forces and systems properties of CRC. We also… CONTINUE READING
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