Transposon-assisted cloning and traceless mutagenesis of adenoviruses: Development of a novel vector based on species D.

@article{Ruzsics2006TransposonassistedCA,
  title={Transposon-assisted cloning and traceless mutagenesis of adenoviruses: Development of a novel vector based on species D.},
  author={Zsolt Ruzsics and Markus Wagner and Andrea Osterlehner and Jonathan D. Cook and Ulrich Koszinowski and Hans-gerhard Burgert},
  journal={Journal of virology},
  year={2006},
  volume={80 16},
  pages={8100-13}
}
Until recently, adenovirus (Ad)-mediated gene therapy was almost exclusively based on human Ad type 5 (Ad5). Preexisting immunity and the limited, coxsackievirus and adenovirus receptor-dependent tropism of Ad5 stimulated attempts to exploit the natural diversity in tropism of the other 50 known human Ad serotypes. Aiming in particular at immunotherapy and vaccination, we have screened representative serotypes from different Ad species for their ability to infect dendritic cells. Ad19a, an Ad… CONTINUE READING
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