Transpositions and translocations induced by site-specific double-strand breaks in budding yeast.

@article{Haber2006TranspositionsAT,
  title={Transpositions and translocations induced by site-specific double-strand breaks in budding yeast.},
  author={James E Haber},
  journal={DNA repair},
  year={2006},
  volume={5 9-10},
  pages={
          998-1009
        }
}
Much of what we know about the molecular mechanisms of repairing a broken chromosome has come from the analysis of site-specific double-strand breaks (DSBs). Such DSBs can be generated by conditional expression of meganucleases such as HO or I-SceI or by the excision of a DNA transposable element. The synchronous creation of DSBs in nearly all cells of the population has made it possible to observe the progress of recombination by monitoring both the DNA itself and proteins that become… CONTINUE READING
BETA