Transposition of hAT elements links transposable elements and V(D)J recombination

@article{Zhou2004TranspositionOH,
  title={Transposition of hAT elements links transposable elements and V(D)J recombination},
  author={Liqin Zhou and Rupak Mitra and Peter W. Atkinson and Alison B. Hickman and Fred Dyda and Nancy L. Craig},
  journal={Nature},
  year={2004},
  volume={432},
  pages={995-1001}
}
Transposons are DNA sequences that encode functions that promote their movement to new locations in the genome. If unregulated, such movement could potentially insert additional DNA into genes, thereby disrupting gene expression and compromising an organism's viability. Transposable elements are classified by their transposition mechanisms and by the transposases that mediate their movement. The mechanism of movement of the eukaryotic hAT superfamily elements was previously unknown, but the… CONTINUE READING

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