Transposition of 9q34 and 22 (q11→qter) regions has a specific role in chronic myelocytic leukemia

@article{Pasquali1979TranspositionO9,
  title={Transposition of 9q34 and 22 (q11→qter) regions has a specific role in chronic myelocytic leukemia},
  author={Francesco Pasquali and Rosario Casalone and D. Francesconi and Diletta Peretti and Marco Fraccaro and Carlo Bernasconi and Mario Lazzarino},
  journal={Human Genetics},
  year={1979},
  volume={52},
  pages={55-67}
}
Six cases are reported of variant Ph′ translocations found among 240 patients with Ph′-positive CML. Five cases had a three-chromosome rearrangement involving, in addition to chromosomes 9 and 22, chromosomes 7, 4, 2(two), and 3 respectively, and one case had a two-chromosome rearrangement 22/5. A review of the literature revealed that three- and two-chromosome variant Ph′ translocations are observed with equal frequency. It is postulated that all variant translocations are indeed three… CONTINUE READING