Transposase and cointegrase: specialized transposition proteins of the bacterial insertion sequence IS21 and related elements

@article{Berger2001TransposaseAC,
  title={Transposase and cointegrase: specialized transposition proteins of the bacterial insertion sequence IS21 and related elements},
  author={Bettina Berger and Drago Haas},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2001},
  volume={58},
  pages={403-419}
}
The bacterial insertion sequence IS21 shares with many insertion sequences a two-step, reactive junction transposition pathway, for which a model is presented in this review: a reactive junction with abutted inverted repeats is first formed and subsequently integrated into the target DNA. The reactive junction occurs in IS21-IS21 tandems and IS21 minicircles. In addition, IS21 shows a unique specialization of transposition functions. By alternative translation initiation, the transposase gene… CONTINUE READING
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