Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies.

@article{Ivics2004TransposableEF,
  title={Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies.},
  author={Zolt{\'a}n Ivics and Zsuzsanna Izsv{\'a}k},
  journal={Methods in molecular biology},
  year={2004},
  volume={260},
  pages={255-76}
}
Functional genomic analyses in vertebrate model systems, including fish, frogs, and mice, have greatly contributed to our understanding of embryonic development and human disease. However, new molecular tools and strategies are needed to meet the increasing demands of linking sequence information to gene function. Transposable elements (TEs) are very efficient at integrating into DNA, and are therefore useful vectors for transferring new genetic material into genomes. In particular, members of… CONTINUE READING