Transposable elements: targets for early nutritional effects on epigenetic gene regulation.

@article{Waterland2003TransposableET,
  title={Transposable elements: targets for early nutritional effects on epigenetic gene regulation.},
  author={Robert A. Waterland and Randy L. Jirtle},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 15},
  pages={5293-300}
}
Early nutrition affects adult metabolism in humans and other mammals, potentially via persistent alterations in DNA methylation. With viable yellow agouti (A(vy)) mice, which harbor a transposable element in the agouti gene, we tested the hypothesis that the metastable methylation status of specific transposable element insertion sites renders them epigenetically labile to early methyl donor nutrition. Our results show that dietary methyl supplementation of a/a dams with extra folic acid… CONTINUE READING
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