Transportin regulates nuclear import of CD44.

@article{Janiszewska2010TransportinRN,
  title={Transportin regulates nuclear import of CD44.},
  author={Michalina Janiszewska and Claudio De Vito and Marie-Aude Le Bitoux and Carlo Fusco and Ivan Stamenkovic},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 40},
  pages={30548-57}
}
CD44 is a facultative cell surface proteoglycan that serves as the principal cell surface receptor for hyaluronan (HA). Studies have shown that in addition to participating in numerous signaling pathways, CD44 becomes internalized upon engagement by ligand and that a portion of its intracellular domain can translocate to the nucleus where it is believed to play a functional role in cell proliferation and survival. However, the mechanisms whereby fragments of CD44 enter the nucleus have not been… CONTINUE READING
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NUMBER 40 JOURNAL OF BIOLOGICAL CHEMISTRY 30557 by gest on July 15

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