Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells.

@article{Levin2010Transportin3A,
  title={Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells.},
  author={Aviad Levin and Zvi Hayouka and Assaf Friedler and Abraham Loyter},
  journal={Nucleus},
  year={2010},
  volume={1 5},
  pages={422-31}
}
Unlike other retroviruses, human immunodeficiency virus type-1 (HIV-1) can infect terminally differentiated cells, due to the ability of its pre-integration complex (PIC) to translocate via the host nuclear pore complex (NPC). The PIC Nuclear import has been suggested to be mediated by the viral integrase protein (IN), via either the importin α or transportin 3 (TNPO3/transportin-SR2) pathways.We show that in virus-infected cells, IN interacts with both importin α and TNPO3, simultaneously or… CONTINUE READING
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