Transportin-1 and Transportin-2: protein nuclear import and beyond.

  title={Transportin-1 and Transportin-2: protein nuclear import and beyond.},
  author={Laure Twyffels and Cyril Gueydan and V{\'e}ronique Kruys},
  journal={FEBS letters},
  volume={588 10},
Nearly 20 years after its identification as a new β-karyopherin mediating the nuclear import of the RNA-binding protein hnRNP A1, Transportin-1 is still commonly overlooked in comparison with its best known cousin, Importin-β. Transportin-1 is nonetheless a considerable player in nucleo-cytoplasmic transport. Over the past few years, significant progress has been made in the characterization of the nuclear localization signals (NLSs) that Transportin-1 recognizes, thereby providing the… CONTINUE READING
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