Transporters involved in resistance to antimalarial drugs.

@article{Valderramos2006TransportersII,
  title={Transporters involved in resistance to antimalarial drugs.},
  author={Stephanie Gaw Valderramos and David A. Fidock},
  journal={Trends in pharmacological sciences},
  year={2006},
  volume={27 11},
  pages={
          594-601
        }
}
The ability to treat and control Plasmodium falciparum infection through chemotherapy has been compromised by the advent and spread of resistance to antimalarial drugs. Research in this area has identified the P. falciparum chloroquine resistance transporter (PfCRT) and the multidrug resistance-1 (PfMDR1) transporter as key determinants of decreased in vitro susceptibility to several principal antimalarial drugs. Transfection-based in vitro studies are consistent with clinical findings of an… CONTINUE READING
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