Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.

@article{Mayerl2014TransportersMA,
  title={Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.},
  author={Steffen Mayerl and Julia Mueller and Reinhard Bauer and Sarah Richert and Celia Mich{\`e}le Kassmann and Veerle M. Darras and Katrin Buder and Anita Boelen and Theo J. Visser and Heike Heuer},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 5},
  pages={
          1987-99
        }
}
Allan-Herndon-Dudley syndrome (AHDS), a severe form of psychomotor retardation with abnormal thyroid hormone (TH) parameters, is linked to mutations in the TH-specific monocarboxylate transporter MCT8. In mice, deletion of Mct8 (Mct8 KO) faithfully replicates AHDS-associated endocrine abnormalities; however, unlike patients, these animals do not exhibit neurological impairments. While transport of the active form of TH (T3) across the blood-brain barrier is strongly diminished in Mct8 KO… CONTINUE READING

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