Transporter-targeted prodrug delivery to improve oral bioavailability of saquinavir

@inproceedings{Wang2013TransportertargetedPD,
  title={Transporter-targeted prodrug delivery to improve oral bioavailability of saquinavir},
  author={Zhiying Wang},
  year={2013}
}
Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and Drug Administration in the United States for the treatment of HIV infection due to its potent anti-HIV activity. However, some unfavorable properties including low aqueous solubility, low intestinal absorption and fast biotransformation lead to its poor oral bioavailability and limited therapeutic efficacy. The objective of this dissertation project is to investigate whether stereoisomerized peptide prodrugs… CONTINUE READING

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