Transporter assays using solid supported membranes: a novel screening platform for drug discovery.

  title={Transporter assays using solid supported membranes: a novel screening platform for drug discovery.},
  author={Bela Kelety and Kerstin Diekert and Joanna Tobien and Natalie Watzke and Wolfgang Dörner and Petr Obrdl{\'i}k and Klaus Fendler},
  journal={Assay and drug development technologies},
  volume={4 5},
Transporters are important targets in drug discovery. However, high throughput-capable assays for this class of membrane proteins are still missing. Here we present a novel drug discovery platform technology based on solid supported membranes. The functional principles of the technology are described, and a sample selection of transporter assays is discussed: the H(+)-dependent peptide transporter PepT1, the gastric proton pump, and the Na(+)/Ca(2+) exchanger. This technology promises to have… 

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