Transport theory for HIV diffusion through in vivo distributions of topical microbicide gels.

@article{Lai2009TransportTF,
  title={Transport theory for HIV diffusion through in vivo distributions of topical microbicide gels.},
  author={Bonnie E. Lai and Marcus H. Henderson and Jennifer J. Peters and David K. Walmer and David F. Katz},
  journal={Biophysical journal},
  year={2009},
  volume={97 9},
  pages={
          2379-87
        }
}
Topical microbicide products are being developed for the prevention of sexually transmitted infections. These include vaginally-applied gels that deliver anti-HIV molecules. Gels may also provide partial barriers that slow virion diffusion from semen to vulnerable epithelium, increasing the time during which anti-HIV molecules can act. To explore the barrier function of microbicide gels, we developed a deterministic mathematical model for HIV diffusion through realistic gel distributions. We… CONTINUE READING
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