Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium.

@article{Brahmajothi2010TransportRT,
  title={Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium.},
  author={M. Brahmajothi and S. Mason and A. Whorton and T. McMahon and R. Auten},
  journal={Free radical biology \& medicine},
  year={2010},
  volume={49 2},
  pages={
          294-300
        }
}
The pathway by which inhaled NO gas enters pulmonary alveolar epithelial cells has not been directly tested. Although the expected mechanism is diffusion, another route is the formation of S-nitroso-L-cysteine, which then enters the cell through the L-type amino acid transporter (LAT). To determine if NO gas also enters alveolar epithelium this way, we exposed alveolar epithelial-rat type I, type II, L2, R3/1, and human A549-cells to NO gas at the air liquid interface in the presence of L- and… Expand
S-nitrosothiol transport via PEPT2 mediates biological effects of nitric oxide gas exposure in macrophages.
Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells.
The use of diaminofluorescein for nitric oxide detection: Conceptual and methodological distinction between NO and nitrosation.
Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.
...
1
2
...

References

SHOWING 1-10 OF 31 REFERENCES
Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter.
Selectivity properties of a Na-dependent amino acid cotransport system in adult alveolar epithelial cells.
Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy.
Alveolar epithelial cells secrete chemokines in response to IL-1beta and lipopolysaccharide but not to ozone.
Identification of Stereoselective Transporters for S-Nitroso-L-cysteine
The biological chemistry of nitric oxide as it pertains to the extrapulmonary effects of inhaled nitric oxide.
  • A. Gow
  • Chemistry, Medicine
  • Proceedings of the American Thoracic Society
  • 2006
Pulmonary 15NO uptake in interstitial lung disease.
...
1
2
3
4
...