Transport protein genes in the murine MHC: possible implications for antigen processing.

@article{Monaco1990TransportPG,
  title={Transport protein genes in the murine MHC: possible implications for antigen processing.},
  author={John J. Monaco and Sungae Cho and Michelle Attaya},
  journal={Science},
  year={1990},
  volume={250 4988},
  pages={1723-6}
}
T lymphocyte activation requires recognition by the T cell of peptide fragments of foreign antigen bound to a self major histocompatibility complex (MHC) molecule. Genetic evidence suggests that part of the class II region of the MHC influences the expression, in trans, of MHC class I antigens on the cell surface, by regulating the availability of peptides that bind to and stabilize the class I molecule. Two closely related genes in this region, HAM1 and HAM2, were cloned and had sequence… CONTINUE READING

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