Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.

@article{Apiwattanakul1999TransportPO,
  title={Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.},
  author={N Apiwattanakul and Takashi Sekine and Arthit Chairoungdua and Yoshikatsu Kanai and Noboru Nakajima and Samaisukh Sophasan and Hitoshi Endou},
  journal={Molecular pharmacology},
  year={1999},
  volume={55 5},
  pages={847-54}
}
Organic anion transporter 1 (OAT1) is the para-aminohippurate (PAH) transporter in the basolateral membrane of the proximal tubule. The present study investigated whether or not nonsteroidal anti-inflammatory drugs (NSAIDs) are transported by OAT1. All of the NSAIDs tested inhibited [14C]PAH uptake via OAT1 expressed in Xenopus laevis oocytes. Ibuprofen, indomethacin, salicylurate, and naproxen showed the strongest potency to inhibit [14C]PAH uptake (Ki approximately 2-10 microM… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
57 Extracted Citations
41 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 57 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…