Transport phenomena in articular cartilage cryopreservation as predicted by the modified triphasic model and the effect of natural inhomogeneities.

@article{Abazari2012TransportPI,
  title={Transport phenomena in articular cartilage cryopreservation as predicted by the modified triphasic model and the effect of natural inhomogeneities.},
  author={Alireza Abazari and R. Bruce Thompson and Janet A. W. Elliott and Locksley E Mcgann},
  journal={Biophysical journal},
  year={2012},
  volume={102 6},
  pages={
          1284-93
        }
}
Knowledge of the spatial and temporal distribution of cryoprotective agent (CPA) is necessary for the cryopreservation of articular cartilage. Cartilage dehydration and shrinkage, as well as the change in extracellular osmolality, may have a significant impact on chondrocyte survival during and after CPA loading, freezing, and thawing, and during CPA unloading. In the literature, Fick's law of diffusion is commonly used to predict the spatial distribution and overall concentration of the CPA in… CONTINUE READING
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