Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine.

@article{Anderson2010TransportOT,
  title={Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine.},
  author={Catriona M H Anderson and Mark Jevons and Muthusamy Thangaraju and Noel Edwards and Nichola J. Conlon and Steven Charles Woods and Vadivel Ganapathy and David T Thwaites},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={332 1},
  pages={
          220-8
        }
}
5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy, fluorescent diagnosis, and fluorescent-guided resection because it leads to accumulation of the photosensitizer protoporphyrin IX (PpIX) in tumor tissues. ALA has good oral bioavailability, but high oral doses are required to obtain selective PpIX accumulation in colonic tumors because accumulation is also observed in normal gut mucosa. Structural similarities between ALA and GABA led us to test the hypothesis that the H… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

An oncologist׳s friend: How Xenopus contributes to cancer research

  • Developmental biology
  • 2015
VIEW 2 EXCERPTS
CITES METHODS & BACKGROUND

Role of solute carriers in response to anticancer drugs

  • Molecular and Cellular Therapies
  • 2014
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Expression cloning of a mammalian proton-coupled oligopeptide transporter

You-jun Fei, Yoshikatsu Kanai, +6 authors Matthias A. Hediger
  • Nature
  • 1994
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer.

  • Biochemical and biophysical research communications
  • 2006
VIEW 4 EXCERPTS

Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy.

  • Journal of photochemistry and photobiology. B, Biology
  • 1992
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL