Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.

@article{Ishiguro2005TransportOT,
  title={Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.},
  author={Naoki Ishiguro and Asami Saito and Kazutoshi Yokoyama and Makoto Morikawa and Takashi Igarashi and Ikumi Tamai},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 4},
  pages={495-9}
}
We investigated the mechanism of renal tubular secretion of the dopamine D2 receptor agonist pramipexole in rats, focusing on organic cation transporters 1 and 2. The uptake of [14C]pramipexole by Xenopus oocytes injected with complementary RNA of either rat organic cation transporter (rOCT) 1 or rOCT2 was significantly higher than that by water-injected oocytes: the kinetic parameters, K(m) and V(max), of pramipexole uptake were 49.5 muM and 234 pmol/60 min/oocyte for rOCT1, and 16.9 microM… CONTINUE READING

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