Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1.

@article{Metzner2004TransportOP,
  title={Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1.},
  author={Linda Metzner and Jutta Kalbitz and Matthias Brandsch},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={309 1},
  pages={28-35}
}
Several proline derivatives such as L-azetidine-2-carboxylic acid, cis-4-hydroxy-L-proline, and 3,4-dehydro-DL-proline prevent procollagen from folding into a stable triple-helical conformation, thereby reducing excessive deposition of collagen in fibrotic processes and the growth of tumors. This study was performed to investigate whether the recently discovered human proton-coupled amino acid transporter 1 (hPAT1) is capable of transporting such pharmacologically relevant proline derivatives… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 43 references

 - aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct

  • PL Nicklin, WJ Irwin, IF Hassan, M Mackay
  • J Pharmacol Exp Ther
  • 2003

Effects of acute

  • MF 1104283–292. Olive, MA Nannini, CJ Ou, HN Koenig, CW Hodge
  • 2002
1 Excerpt

Effects of acute acamprosate and homotaurine on ethanol intake and ethanol - stimulated mesolimbic dopamine release

  • G Ranaldi, K Islam, Y Sambuy
  • Eur J Pharmacol
  • 2002

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