Transport of pefloxacin across the bacterial cytoplasmic membrane in quinolone-susceptible Staphylococcus aureus.

@article{Furet1992TransportOP,
  title={Transport of pefloxacin across the bacterial cytoplasmic membrane in quinolone-susceptible Staphylococcus aureus.},
  author={Y. X. Furet and Jacques P M Deshusses and J. C. P{\'e}ch{\`e}re},
  journal={Antimicrobial agents and chemotherapy},
  year={1992},
  volume={36 11},
  pages={2506-11}
}
Binding to phospholipids, uptake by simple diffusion, and an energy-dependent, carrier-mediated efflux are thought to characterize interactions between fluoroquinolones and bacterial cytoplasmic membranes. Here, we have found that an endogenous active efflux is unlikely in quinolone-susceptible Staphylococcus aureus. The protonophore, carbonyl cyanide m-chlorophenylhydrazone (CCCP), increased pefloxacin uptake in different membrane systems under conditions which excluded carrier-mediated… CONTINUE READING

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