Transport of organic anions across the basolateral membrane of proximal tubule cells.

@article{Burckhardt2003TransportOO,
  title={Transport of organic anions across the basolateral membrane of proximal tubule cells.},
  author={Birgitta Christina Burckhardt and Gerhard Burckhardt},
  journal={Reviews of physiology, biochemistry and pharmacology},
  year={2003},
  volume={146},
  pages={
          95-158
        }
}
Renal proximal tubules secrete diverse organic anions (OA) including widely prescribed anionic drugs. Here, we review the molecular properties of cloned transporters involved in uptake of OA from blood into proximal tubule cells and provide extensive lists of substrates handled by these transport systems. Where tested, transporters have been immunolocalized to the basolateral cell membrane. The sulfate anion transporter 1 (sat-1) cloned from human, rat and mouse, transported oxalate and sulfate… CONTINUE READING
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