Transport of molecules, particles, and cells in solid tumors.

  title={Transport of molecules, particles, and cells in solid tumors.},
  author={Rakesh K. Jain},
  journal={Annual review of biomedical engineering},
  • R. Jain
  • Published 1999
  • Biology, Chemistry
  • Annual review of biomedical engineering
Extraordinary advances in molecular biology and biotechnology have led to the development of a vast number of therapeutic anti-cancer agents. To reach cancer cells in a tumor, a blood-borne therapeutic molecule, particle, or cell must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, which it then must migrate through. Unfortunately, tumors often develop in ways that hinder these steps. The goal of research in this area is to analyze each of… 

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Delivery of Molecular and Cellular Medicine to Solid Tumors

  • R. Jain
  • Biology
    Journal of controlled release : official journal of the Controlled Release Society
  • 1998
A paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiologic barriers in solid tumors and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.

  • S. HobbsW. Monsky R. Jain
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
Delivery may be less efficient in cranial tumors than in subcutaneous tumors, delivery may be reduced during tumor regression induced by hormonal ablation, and permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter.

Transport of molecules in the tumor interstitium: a review.

  • R. Jain
  • Materials Science
    Cancer research
  • 1987
High interstitial pressure and low microvascular pressure may retard extravasation of molecules and cells in the tumor interstitium, especially in large tumors.

Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.

It is indicated that A-NK cells bind in high numbers to segments of the vessels of mammary tumors growing in an intracranial site when administered through an arterial route; however, some tumor vessels may escape recognition by these cells.

Suppression of tumor growth in vivo by local and systemic 90K level increase.

A role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression, is suggested.

Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.

The first quantitative study of the in vivo movement of fluorescently labeled adherent lymphokine-activated killer (A-LAK) cells is presented, suggesting that in addition to direct cytotoxicity, the response to adoptive immunotherapy is mediated via the tumor vasculature.

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

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Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.

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It is postulate that modulation of tumor microvascular pressure (MVP) and associated changes in IFP would enhance macromolecular delivery into a solid tumor.

Interstitial hypertension in human breast and colorectal tumors.

Results agree with the findings of 3 previous studies examining IFP in human superficial melanomas, and indicate that in all types of human tumors studied to date, IFP was significantly elevated above that of normal tissue.