Transport of lipoprotein lipase across endothelial cells.

  title={Transport of lipoprotein lipase across endothelial cells.},
  author={Umesh Saxena and Michael G. Klein and Ira J Goldberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={88 6},
Lipoprotein lipase (LPL), synthesized in muscle and fat, hydrolyzes plasma triglycerides primarily while bound to luminal endothelial cell surfaces. To obtain information about the movement of LPL from the basal to the luminal endothelial cell surface, we studied the transport of purified bovine milk LPL across bovine aortic endothelial cell monolayers. 125I-labeled LPL (125I-LPL) added to the basal surface of the monolayers was detected on the apical side of the cells in two compartments: (i… CONTINUE READING
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