Transport of leukotriene C4 and structurally related conjugates.

  title={Transport of leukotriene C4 and structurally related conjugates.},
  author={Gabriele Jedlitschky and Dietrich Keppler},
  journal={Vitamins and hormones},
Transport proteins control the release of the endogenous glutathione conjugate leukotriene C4 (LTC4) from leukotriene-synthesizing cells as well as its hepatobiliary and renal elimination. The photolabile conjugated triene structure of LTC4 has enabled direct photoaffinity labeling of the multidrug resistance protein 1 (MRP1, symbol ABC C1) in membranes from mastocytoma cells, leading to the identification of the function of this protein as an ATP-dependent export pump for LTC4 and structurally… CONTINUE READING