Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system.

@article{Suzuki1989TransportOI,
  title={Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system.},
  author={Hodaka Suzuki and Yasufumi Sawada and Yuichi Sugiyama and Tatsuji Iga and Manabu Hanano and Reynold Spector},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={250 3},
  pages={979-84}
}
The transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system (CNS) was studied using in vivo, in situ and in vitro experimental techniques. After i.v. bolus administration, the imipenem concentration in the cerebrospinal fluid (CSF) rose to a peak within 30 min and declined with time. The CSF/serum unbound concentration ratio of imipenem was 0.22 at 2 hr after i.v. administration, substantially higher than that reported for benzylpenicillin. By using an in situ… CONTINUE READING